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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
12.12
Human Site:
S19
Identified Species:
22.22
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
S19
M
P
Q
S
K
G
K
S
K
R
K
K
D
L
R
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
T23
D
G
S
A
V
N
G
T
S
S
A
E
T
N
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
S19
M
P
Q
T
K
G
K
S
K
R
K
K
D
L
R
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
S19
L
P
Q
T
K
G
K
S
K
R
K
K
D
L
R
Rat
Rattus norvegicus
Q4KSH7
419
47517
L75
P
S
R
P
R
H
M
L
G
L
P
S
T
L
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
K24
R
S
R
K
L
S
R
K
P
K
K
R
K
D
L
Chicken
Gallus gallus
Q90891
398
44059
G25
P
A
E
G
P
G
P
G
G
S
A
E
A
N
L
Frog
Xenopus laevis
Q07192
446
50082
S104
Q
K
Q
D
L
R
T
S
G
A
K
A
L
S
T
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
K35
S
N
V
R
G
K
K
K
L
P
K
E
L
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
K14
L
T
P
F
T
I
A
K
E
P
E
A
A
I
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
S21
S
L
R
P
T
S
L
S
T
R
P
T
S
L
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
F25
Q
E
S
P
I
S
S
F
L
T
A
S
G
T
F
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
G315
N
S
G
S
S
G
G
G
G
L
F
A
N
F
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
0
N.A.
93.3
N.A.
86.6
6.6
N.A.
6.6
6.6
20
13.3
N.A.
0
N.A.
20
N.A.
P-Site Similarity:
100
20
N.A.
100
N.A.
100
20
N.A.
33.3
20
20
20
N.A.
26.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
0
8
0
0
8
24
24
16
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
0
0
0
0
0
0
0
0
24
8
0
% D
% Glu:
0
8
8
0
0
0
0
0
8
0
8
24
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
8
0
0
8
0
0
8
16
% F
% Gly:
0
8
8
8
8
39
16
16
31
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
8
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
8
0
8
24
8
31
24
24
8
47
24
8
8
0
% K
% Leu:
16
8
0
0
16
0
8
8
16
16
0
0
16
39
31
% L
% Met:
16
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
0
0
0
8
0
0
0
0
0
0
8
16
0
% N
% Pro:
16
24
8
24
8
0
8
0
8
16
16
0
0
0
0
% P
% Gln:
16
0
31
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
24
8
8
8
8
0
0
31
0
8
0
0
24
% R
% Ser:
16
24
16
16
8
24
8
39
8
16
0
16
8
8
16
% S
% Thr:
0
8
0
16
16
0
8
8
8
8
0
8
16
8
8
% T
% Val:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _